Determining the complications, mortality, and treatment of patients hospitalized at Baharloo hospital due to oral hypoglycemic drugs toxicity in 2008-9

نویسندگان

  • Behnam Behnoosh Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Fakhrodin Taghdosi Nejad Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Mohammad Arefi Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Mohammad Jamalian Department of Forensic Medicine, Arak University of Medical Sciences, Arak, Iran
  • Rasoul Roshani Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran Iran
چکیده مقاله:

Background: Glybenclamide and metformin are two of the most common oral hypoglycemic drugs which are often used in treatment of type II diabetes mellitus. Toxicity due to these drugs may occur intentionally, accidentally, or even at the normal dosage because of the progression of such internal diseases as renal dysfunction. Methods: In this case series study, 59 patients poisoned with oral hypoglycemic agents referring to Baharloo Hospital were evaluated between March 2009 and September 2010. Results: The most common clinical findings were lethargy (66.7%) and drowsiness (66.7%) that were mostly observed in patients who had concomitantly ingested glybenclamide and metformin. Metabolic acidosis was observed in 33.3% of the patients who had ingested metformin alone and 22.2 % of the patients who had ingested metformin together with glybenclamide. Some degrees of hypoglycemia were observed in 50.8% of the patients upon admission nevertheless, severe hypoglycemia was seen only in 17% of them. The majority of the patients got improved within 3 days of hospitalization and got discharged. Although due to the severity of toxicity and its associated complications, 22.8% of the patients needed more than 3 days of hospitalization, permanent neurological complications and mortality did not happen to any of the patients. Conclusion: Glybenclamide overdose leads to hypoglycemia and it can be prevented by careful monitoring of blood glucose and immediate treatment with intravenous dextrose, mostly occuring due to its hypoglycemic effects on the brain.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

determining the complications, mortality, and treatment of patients hospitalized at baharloo hospital due to oral hypoglycemic drugs toxicity in 2008-9

background: glybenclamide and metformin are two of the most common oral hypoglycemic drugs which are often used in treatment of type ii diabetes mellitus. toxicity due to these drugs may occur intentionally, accidentally, or even at the normal dosage because of the progression of such internal diseases as renal dysfunction. methods: in this case series study, 59 patients poisoned with oral hypo...

متن کامل

Survey of Respiratory and Urogenital Infections Due to Mycoplasma in the Hospitalized Patients in Ahwaz Imam Khomeini Hospital

Mycoplasma are the smallest free–living organisms which can grow on artificial media. Although some Mycoplasma are normal commensals, others are proven pathogens of respiratory and urogenital tracts.In this survey, 221 collected samples of 121 patients with urogenital infections (54.7%) and 100 patients with respiratory infections (45.3%) were examined. These patients were either referred to or...

متن کامل

BACTERIURIA DUE TO CATHETERIZATION IN HOSPITALIZED PATIENTSBACTERIURIA DUE TO CATHETERIZATION IN HOSPITALIZED PATIENTS

In this survey, made to determine instances of bacteriuria occurring in hospitalized patients who had undergone catheterization, 259 urine specimens were taken from 103 patients admitted to three hospitals in Tehran. Of the 73 patients who had no urinary tract infection or contamination, 40 (54.8%) developed bacteriuria at the end of catheterization. Incidence of bacteriuria in patients un...

متن کامل

the role of russia in transmission of energy from central asia and caucuses to european union

پس ازفروپاشی شوروی،رشد منابع نفت و گاز، آسیای میانه و قفقاز را در یک بازی ژئوپلتیکی انرژی قرار داده است. با در نظر گرفتن این منابع هیدروکربنی، این منطقه به یک میدانجنگ و رقابت تجاری برای بازی های ژئوپلتیکی قدرت های بزرگ جهانی تبدیل شده است. روسیه منطقه را به عنوان حیات خلوت خود تلقی نموده و علاقمند به حفظ حضورش می باشد تا همانند گذشته گاز طبیعی را به وسیله خط لوله مرکزی دریافت و به عنوان یک واس...

15 صفحه اول

Methadone Overdose and Its Complications in Patients Admitted to ‎the Toxicology Emergency Ward of Baharloo Hospital of Tehran in ‎‎2011-2012‎

Background: To date, studies on methadone overdose in adults have not been ‎reported in Iran. Hence, this study was performed to determine the frequency of ‎methadone overdose and its associated complications in Baharloo Hospital of Tehran ‎between August 2011 and August 2012.‎ Methods: This cross-sectional study was done on 390 cases. All patients with ‎methadone overdoses and positive urine ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 4  شماره None

صفحات  367- 372

تاریخ انتشار 2011-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023